See Schedule of Copa Sudamericana: Round of 16

Goias – Cerro Porteno (PAR)
Botafogo – Emelec (ECU)

Internacional – Univ. de Chile (CHI)
Alianza Atletico (PER) – Fluminense

Velez Sarsfield (ARG) – Union Espanola (CHI)
LDU (ECU) – Lanus (ARG)

River Plate (URU) – Vitoria
San Lorenzo (ARG) – Cienciano (PER)